The anti-MRSA resource: a comprehensive archive of anti-MRSA peptides and essential oils

Methicillin-resistant Staphylococcus aureus (MRSA), a major cause of fatalities due to Antimicrobial Resistance (AMR), can act as an opportunistic pathogen despite being part of the normal human flora. MRSA infections, such as skin infections, pneumonia, sepsis, and surgical site infections, have risen significantly, with bloodstream infection cases increasing from 21% in 2016 to 35% in 2020. This surge has prompted research into alternative treatments like nanomaterials, photodynamic therapy, antimicrobial peptides (AMPs), and essential oils (EOs). AMPs and EOs have shown higher success rates compared to other alternatives, gaining significant attention for their effectiveness against MRSA. In this perspective, we have created a database for peptides and EOs that have been discovered to treat MRSA. Manual data curation was done to get related information on each of the anti-MRSA EOs and AMPs from the PubMed articles. This led to the curation of 1789 peptides (1029 unique) and 863 EOs (671 unique) that have been reported against MRSA. This was followed by database creation and the development of tools for sequence analysis and determination of physiochemical properties. This resource has been named 'The Anti-MRSA Resource' or 'TAMRSAR' which we believe will aid in future drug development efforts to combat the diseases caused by MRSA. The database is accessible on any web browser at the URL: https://bblserver.org.in/tamrsar/.