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Updated: May 7, 2025

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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
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Effect of Biomedical Hydrogels on Exercise-induced Muscle Damage: A Narrative Review.
Jie Cai1, Mingbo Fan2, Ailin Yu3
1Department of Orthopaedics, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, 311200, Zhejiang, China.
Current Medicinal Chemistry
|January 6, 2025
Summary
Biomedical hydrogels offer a promising new approach to managing exercise-induced muscle damage (EIMD). These advanced materials can help alleviate pain and inflammation, promoting faster recovery for athletes.
Area of Science:
- Biomedical Engineering
- Materials Science
- Sports Medicine
Background:
- Exercise-induced muscle damage (EIMD) is prevalent in athletes, causing pain and reduced functionality.
- Current treatments like RICE and NSAIDs have limitations in efficacy and long-term outcomes.
- Innovative strategies are needed for effective EIMD management and injury prevention.
Purpose of the Study:
- To provide a comprehensive overview of biomedical hydrogels for EIMD.
- To explore hydrogels as a preventive and alleviative approach for muscle damage.
- To discuss current challenges and future research directions in this field.
Main Methods:
- Review of existing literature on biomedical hydrogels and EIMD.
- Analysis of hydrogel properties relevant to muscle tissue repair.
- Discussion of drug-delivery and mechanical support capabilities of hydrogels.
Main Results:
- Hydrogels possess unique properties suitable for muscle damage management.
- They offer potential for drug delivery and mechanical support to injured muscle tissue.
- Biomedical hydrogels show promise in both preventing and alleviating EIMD.
Conclusions:
- Biomedical hydrogels represent a significant advancement in EIMD treatment.
- Further research is warranted to optimize hydrogel design and application for muscle recovery.
- Hydrogels hold potential for enhancing athletic performance and reducing injury recurrence.

