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Role of IL-6, TNF-α and VCAM-1 as predictors of renal impairment in patients with spontaneous bacterial peritonitis

  • 0Endemic Medicine and Hepato-Gastroenterology Department, Faculty of Medicine, Cairo University, Cairo 3753450, Egypt.
Transactions of the Royal Society of Tropical Medicine and Hygiene +

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January 6, 2025

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January 6, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Interleukin-6, tumour necrosis factor-alpha, and vascular cell adhesion molecule-1 are not reliable predictors of renal impairment (RI) or mortality in cirrhotic patients with spontaneous bacterial peritonitis (SBP). These biomarkers showed limited diagnostic value in the study.

Area Of Science

  • Hepatology and Nephrology
  • Clinical Immunology
  • Biomarker Discovery

Background

  • Renal impairment (RI) is a complication in cirrhotic patients with spontaneous bacterial peritonitis (SBP).
  • Systemic inflammatory response syndrome, involving cytokines like interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and vascular cell adhesion molecule-1 (VCAM-1), may contribute to RI in SBP.
  • The diagnostic utility of these specific cytokines as predictors of RI and mortality in this patient population requires investigation.

Purpose Of The Study

  • To evaluate the predictive role of IL-6, TNF-α, and VCAM-1 serum levels for renal impairment (RI) and mortality.
  • To assess the diagnostic accuracy of these biomarkers in cirrhotic patients diagnosed with spontaneous bacterial peritonitis (SBP).

Main Methods

  • A cohort of 90 cirrhotic patients with SBP was studied.
  • Patients were divided into two groups: without RI (Group A) and with RI (Group B).
  • Serum levels of IL-6, TNF-α, and VCAM-1 were measured using enzyme-linked immunosorbent assay (ELISA).

Main Results

  • Renal impairment (RI) was present in 50% of the patients.
  • Elevated levels of IL-6, TNF-α, and VCAM-1 were observed in a small proportion of patients (11.1%, 8.9%, and 6.7%, respectively).
  • No significant differences in cytokine levels were found between patients with and without RI, and their predictive value for RI was limited (AUC=0.5).

Conclusions

  • Tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and vascular cell adhesion molecule-1 (VCAM-1) lack sufficient diagnostic value.
  • These biomarkers are not recommended for predicting renal impairment (RI) or mortality in cirrhotic patients with spontaneous bacterial peritonitis (SBP).

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