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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
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Current status of FAP-directed cancer theranostics: a bibliometric analysis

Dan Ruan1,2, Simin Wu1, Xuehua Lin1

  • 1Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Development and Translation of Radiopharmaceuticals, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.

Biophysics Reports
|January 6, 2025
PubMed

Insights

This bibliometric analysis maps global research on Fibroblast Activation Protein (FAP) and its radiotracers for cancer imaging. It highlights key trends, influential publications, and future research directions in FAP inhibitor (FAPI) PET imaging.

Area of Science:

  • Oncology
  • Radiochemistry
  • Bibliometrics

Background:

  • Fibroblast Activation Protein (FAP) is crucial in oncology for tumor diagnosis and treatment.
  • Quinoline-based FAP inhibitors (FAPIs) are promising radiotracers for Positron Emission Tomography (PET) imaging in cancer.
  • Bibliometric analysis provides insights into research trends and productivity in scientific fields.

Purpose of the Study:

  • To conduct a bibliometric analysis of scientific publications on FAP and FAPI-based radiotracers.
  • To quantify and visualize research trends, collaborations, and influential elements in FAP research.
  • To identify current hotspots and future research directions in FAPI PET imaging.

Main Methods:

  • Bibliometric analysis using R and VOSviewer on Web of Science Core Collection data.
  • Quantification and visualization of publications by country, institute, author, journal, and keywords.
  • Examination of FAPI radiotracer studies, including methodology, radionuclides, imaging instruments, and associated diseases.

Main Results:

  • 2,664 FAP-related publications identified from 1992 to present.
  • Germany, USA, and China lead in publications and collaborations; Southwest Medical University is the most productive institute.
  • Key terms include FAP, 68Ga-FAPI, and PET/CT; influential journals are European Journal of Nuclear Medicine and Molecular Imaging and Journal of Nuclear Medicine.

Conclusions:

  • Bibliometric data reveals significant global research activity and collaboration in FAP and FAPI radiotracer development.
  • The analysis highlights key players, influential publications, and dominant research themes in the field.
  • This study provides a comprehensive overview to guide future research efforts in FAP-targeted cancer imaging.
Keywords:
Bibliometric analysisCancerFAPIFibroblast activation proteinPET/CTRadionuclide

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