Overview of porous magnesium-based scaffolds: development, properties and biomedical applications

Magnesium (Mg) and its alloys are revolutionizing the field of interventional surgeries in the medical industry. Their high biocompatibility, biodegradability, and a similar elastic modulus to natural bone make porous Mg-based structures potential candidates for orthopedic implants and tissue engineering scaffolding. However, fabricating and machining porous Mg-based structures is challenging due to their complexity and difficulties in achieving uniform or gradient porosity. This review aims to thoroughly explore various fabrication procedures used to create metallic scaffolds, with a specific focus on those made from Mg-based alloys. Both traditional manufacturing techniques, including the directional solidification of metal-gas eutectic technique, pattern casting, methods using space holders, and modern fabrication methods, which are based on additive manufacturing, are covered in this review article. Furthermore, the paper highlights the most important findings of recent studies on Mg-based scaffolds in terms of their microstructure specifications, mechanical properties, degradation and corrosion behavior, antibacterial activity, and biocompatibility (both in vivo and in vitro). While extensive research has been conducted to optimize manufacturing parameters and qualities of Mg-based scaffolds for use in biomedical applications, specifically for bone tissue engineering applications, further investigation is needed to fabricate these scaffolds with specific properties, such as high resistance to corrosion, good antibacterial properties, osteoconductivity, osteoinductivity, and the ability to elicit a favorable response from osteoblast-like cell lines. The review concludes with recommendations for future research in the field of medical applications.