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Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment
Ben Milborne1, Andi Arjuna1,2, Md Towhidul Islam1
1Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K.
ACS Omega
|January 6, 2025
Summary
High yttrium-content phosphate glass-ceramic microspheres were developed for bone cancer radiotherapy. These biomaterials exhibit excellent cytocompatibility and chemical durability, showing promise for combined cancer treatment and bone regeneration.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Radiotherapy Engineering
Background:
- Bone cancer treatment requires advanced biomaterials for radiotherapy and regeneration.
- Phosphate-based glasses offer potential but require modification for enhanced therapeutic properties.
Purpose of the Study:
- To develop and characterize high yttrium-content phosphate-based glass-ceramic microspheres.
- To evaluate their suitability for bone cancer radiotherapy and bone regeneration applications.
Main Methods:
- Microspheres were synthesized using flame spheroidization with varying yttrium oxide ratios.
- Characterization involved Energy Dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), ion release studies, and in vitro cytocompatibility assays.
Main Results:
- Microspheres displayed a narrow size distribution (45-125 μm) and homogeneous elemental distribution.
- Yttrium content increased up to 39 mol%, forming Y2O3 and Y(PO4) crystalline phases.
- Reduced ion release rates, stable pH, and favorable cellular responses (metabolic and alkaline phosphatase activity) were observed.
Conclusions:
- High yttrium-content phosphate glass-ceramic microspheres are successfully produced with tunable properties.
- These microspheres demonstrate excellent chemical durability and cytocompatibility.
- They represent promising versatile biomaterials for combined bone cancer radiotherapy and bone regeneration.
