Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

146
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
146
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

101
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
101
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

178
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
178
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

588
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
588
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

5.8K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
5.8K
Drug Delivery: Overview01:16

Drug Delivery: Overview

243
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
243

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self Emulsifying Delivery System of Cissus quadrangularis: Evidence of Enhanced Efficacy and Promising Pharmacokinetic Profile in the Management of Osteoporosis.

AAPS PharmSciTech·2024
Same author

Utilization and characterization of flaxseed oil in ultrasonically emulsified mango beverage.

Journal of food science and technology·2022
Same author

Characterization and cytotoxic activity of pigment extracted from <i>Rhodotorula mucilaginosa</i> to assess its potential as bio-functional additive in confectionary products.

Journal of food science and technology·2021
Same author

Moth bean starch (<i>Vigna aconitifolia</i>): isolation, characterization, and development of edible/biodegradable films.

Journal of food science and technology·2019

Related Experiment Video

Updated: May 7, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

972

Nutraceutical delivery vehicles: enhanced stability, bioavailability.

Gargi Ghoshal1

  • 1Dr. S. S. Bhatnagar University Institute of Chemical Engineering & Technology, Panjab University, Chandigarh, 160014 India.

Food Science and Biotechnology
|January 6, 2025
PubMed
Summary

Nanotechnology enhances food and agriculture by improving bioactive compound delivery. This review explores various nanocarrier systems for controlled nutraceutical release and bioavailability.

Keywords:
Bio-accessibilityBioavailabilityNanotechnologyNutraceutical delivery vehicleNutraceuticals

More Related Videos

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

991
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K

Related Experiment Videos

Last Updated: May 7, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

972
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

991
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K

Area of Science:

  • Food Science and Technology
  • Agricultural Science
  • Materials Science

Background:

  • Nanotechnology offers significant advancements in food and agriculture.
  • Reducing particle size to the nanoscale enhances surface area and reactivity.
  • Nanotechnology can improve the solubility, stability, and bioavailability of nutraceuticals.

Purpose of the Study:

  • To review nanodelivery systems for nutraceuticals in food and agriculture.
  • To discuss formulations and principles of various nanocarriers.
  • To highlight recent research in nanodelivery technologies.

Main Methods:

  • Literature review of nanotechnology applications in nutraceutical delivery.
  • Analysis of various nanocarrier systems including phospholipid, liposomes, niosomes, emulsions, nanoemulsions, ethosomes, SNEDDS, SLN, and NLCs.
  • Discussion of formulation strategies and underlying principles.

Main Results:

  • Nanotechnology enables site-specific and controlled release of nutraceuticals.
  • Various nanocarriers demonstrate enhanced bioavailability and stability of bioactive compounds.
  • Nanostructured lipid carriers (NLCs) and other systems offer promising solutions for nutraceutical delivery.

Conclusions:

  • Nanotechnology provides innovative solutions for enhancing nutraceutical utilization in food and agriculture.
  • The discussed nanodelivery systems offer improved control over release and bioavailability.
  • Further research into these nanotechnologies will advance food and agricultural applications.