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Updated: May 7, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Feasibility of a Low-Intensity Intervention to Influence Antibiotic Prescribing Rates Use in Outpatient Settings: A
Taissa A Bej1, Brigid M Wilson1,2, Ukwen C Akpoji3
1Geriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, Ohio, USA.
Primary care providers receiving feedback on antibiotic use and adverse events reduced prescription rates for acute respiratory infections. This intervention improved antibiotic stewardship and patient safety outcomes.
Area of Science:
- Infectious Diseases
- Public Health
- Health Services Research
Background:
- Antibiotic overuse contributes to adverse events and resistance.
- Primary care providers (PCPs) may alter prescribing habits with awareness of negative impacts.
Purpose of the Study:
- To evaluate the impact of comparative feedback and adverse event notifications on PCP antibiotic prescribing for acute respiratory infections.
Main Methods:
- A cluster randomized controlled trial was conducted across 12 Veterans Affairs outpatient clinics.
- Intervention group PCPs received quarterly antibiotic use reports and adverse event alerts.
- Antibiotic prescription rates were compared across preintervention, intervention, and postintervention periods.
Main Results:
- Intervention clinics showed no significant change in antibiotic prescription rates during the preintervention period.
- However, intervention clinics demonstrated significantly lower antibiotic prescription rates during the intervention and postintervention periods compared to control clinics.
- No differences were observed in emergency department visits or hospitalizations between groups.
Conclusions:
- A low-intensity intervention combining comparative feedback with adverse event notifications effectively reduced antibiotic prescription rates among PCPs.
- This approach shows promise for improving antibiotic stewardship in primary care settings.
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