Chelidonic acid abrogates oxidative stress and memory dysfunction in experimental aging rats
Feride Nihal Sinan1, Emel Serdaroğlu Kaşikçi2,3, Burcu Çevreli2
1Graduate School of Science, Department of Biotechnology, Üsküdar University, İstanbul, Turkiye.
Turkish Journal of Biology = Turk Biyoloji Dergisi
|January 6, 2025
Summary
Chelidonic acid (CA) improved cognitive function in an aging rat model. It increased total antioxidant status (TAS) and brain-derived neurotrophic factor (BDNF) levels, suggesting benefits for neurodegenerative disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Aging is associated with cognitive decline and oxidative stress.
- D-galactose (D-gal) is used to induce an aging model in rats.
- Chelidonic acid (CA) is investigated for its potential therapeutic effects.
Purpose of the Study:
- To evaluate the effects of chelidonic acid (CA) on cognitive function in a D-galactose-induced aging rat model.
- To assess the impact of CA on oxidative stress markers (GSH, MDA) and neurotrophic factors (BDNF).
Main Methods:
- An aging rat model was established using D-galactose administration.
- Rats were divided into control, CA, D-gal, and D-gal + CA groups.
- Cognitive function was assessed using novel object recognition and Morris water maze tests.
- Biochemical analyses measured glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS), and BDNF levels in serum and hippocampus.
Main Results:
- D-galactose administration impaired cognitive function.
- Chelidonic acid treatment improved memory and reduced the time to find the platform in the Morris water maze.
- CA treatment decreased MDA levels and increased GSH, TAS, and BDNF levels in serum and hippocampus.
Conclusions:
- Chelidonic acid demonstrates neuroprotective effects in an aging rat model.
- CA positively influences cognitive function and memory processes.
- Increased TAS and BDNF levels are key mechanisms underlying CA's benefits.
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