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Updated: May 7, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Visible-light-induced radical cascade sulfonylation/cyclization towards indole-fused pyridine derivatives
Qin Du1, Ruohan Pan2, Yu Chen2
1Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) Changde 415000 China duqin1009@163.com.
Abstract:
Indole-fused pyridines are an important motif in pharmaceuticals and functional molecules. A visible-light induced Ru(bpy)3Cl2·6H2O catalyzed radical cascade sulfonylation/cyclization strategy for the synthesis of indole-fused pyridine derivatives was developed. Diverse indole-fused pyridines bearing different functional groups were obtained in moderate to good yields. Compared with previous work, the easily accessible starting materials, molecular nitrogen as byproduct, and eco-friendly visible light as an energy source all make this transformation more sustainable and practical.
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