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Catalytic peptide/hemin complex from ester-amide exchange reaction mediated by deep eutectic solvents

Cheng-Hsi Wang¹, Yao-Yu Jhang¹, Sheng-Sheng Yu^1,2,3

¹Department of Chemical Engineering, National Cheng Kung University Tainan 70101 Taiwan ssyu@mail.ncku.edu.tw.

|January 6, 2025

Abstract:

The functions of peptides often emerge upon their self-assembly or binding with other co-factors. However, the synthetic complexity makes these functional peptides intractable. Here, we utilize the ester-amide exchange reaction in deep eutectic solvents to generate peptide libraries from unactivated amino acids. This strategy leads to peptide mixtures that exhibit hemin-binding capability and peroxidase-like activity.

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