Genomic insights into Neolithic founding paternal lineages around the Qinghai-Xizang Plateau using integrated YanHuang resource
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View abstract on PubMed
Summary
This summary is machine-generated.The Y chromosome analysis of 9,901 individuals reveals the ancient origins and migrations of Tibeto-Burman (TB) populations on the Qinghai-Xizang Plateau. Two key TB lineages expanded around 5,000 years ago, shaping paternal genetic structures in the region.
Area Of Science
- Population Genetics
- Human Evolution
- Ancient DNA Analysis
Background
- Indigenous populations of the Qinghai-Xizang Plateau display unique high-altitude adaptations, particularly Tibeto-Burman (TB) groups.
- The paternal genetic history of the eastern Plateau regions is less understood.
Purpose Of The Study
- To investigate the paternal genetic heritage of the Qinghai-Xizang Plateau, focusing on eastern regions.
- To reveal the Paleolithic origins and Holocene expansions of ancestral populations on the Plateau.
Main Methods
- Integrated Y chromosome dataset of 9,901 modern and ancient individuals.
- Whole Y chromosome sequencing (1,297 individuals) and Y-SNP/STR genotyping.
Main Results
- Identified Paleolithic common origin and divergence of Plateau ancestors from East Asian lowlands.
- Revealed two key TB-related founding lineages (D-Z31591 and O-CTS4658) with significant expansions ~5,000 years ago.
- Established genetic links between Plateau populations and lowland southwestern China via migration pathways.
Conclusions
- Paternal genetic structures align with East Asian geography and linguistic groups.
- Y chromosome analysis is valuable for reconstructing complex paternal histories of high-altitude populations.
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