Weight-neutral early time-restricted eating improves glycemic variation and time in range without changes in...

Area of Science:

• Metabolic health
• Chrononutrition
• Prediabetes management

Background:

• Early time-restricted eating (eTRE) involves consuming calories within the first 6-8 hours of the day.
• eTRE may offer metabolic benefits independent of weight loss, but its effects on glycemic control and inflammation are not fully understood.

Purpose of the Study:

• To investigate the weight-independent effects of eTRE on glycemic variation, time-in-range metrics, and inflammatory markers in adults with prediabetes.

Main Methods:

• A randomized crossover feeding study involving 10 adults with prediabetes.
• Participants were assigned to either an 8-hour eTRE schedule or a usual feeding schedule for one week, followed by a crossover to the other schedule.
• Continuous glucose monitoring was used to assess glycemic parameters.

Main Results:

• eTRE significantly decreased glycemic variation (mean amplitude of glycemic excursion).
• eTRE reduced time spent in hyperglycemia (above 140 mg/dL).
• No significant changes were observed in inflammatory markers (erythrocyte sedimentation rate and C-reactive protein).

Conclusions:

• eTRE demonstrates potential as a dietary intervention for managing dysglycemia independently of weight loss in individuals at high risk.
• eTRE may be a valuable tool for improving glycemic control in prediabetes.