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Updated: May 7, 2025

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Successful treatment of recurrent refractory Kaposi's sarcoma in AIDS: a case report

Feng Li1, Rongrong Zheng1, Jun Yan1

  • 1The Second Infectious Disease Department, Xixi Hospital of Hangzhou, Hangzhou, China.

Frontiers in Oncology
|January 6, 2025
PubMed

Kaposi's sarcoma (KS) is a soft tissue lesion that resembles a hyperpigmented angiosarcoma and is typically associated with human herpesvirus 8 (HHV-8) infection. It is most frequently observed in immunocompromised patients, particularly those with AIDS, and is also referred to as HIV-associated Kaposi's sarcoma (AIDS-KS). The disease progresses rapidly, is challenging to manage, and has a high mortality rate. This case report presents a patient with AIDS-KS who experienced relapse after chemotherapy with anthracyclines. Subsequent chemotherapy with the same method had no significant effect. However, complete remission was achieved after the addition of a programmed cell death protein 1(PD-1) inhibitor, as confirmed by pathological biopsy. The PD-1 inhibitor was well-tolerated and had few adverse effects. It also helped to improve the immune reconstitution of the patient. The report highlights the remarkable efficacy of the PD-1 inhibitor in treating AIDS-KS. This provides case support for PD-1 inhibitors for AIDS-KS.

Keywords:
Keywords: AIDS-related Kaposi’s sarcomaPD-1 inhibitorcase reportcomplete remissionimmunotherapy

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