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Updated: May 7, 2025

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A High Spatiotemporal Iontronic Single-Cell Viscometer.

Tianyang Zhang1, Siyuan Yu1, Bing Wang1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Research (Washington, D.C.)
|January 6, 2025
PubMed
Summary
This summary is machine-generated.

A novel iontronic single-cell viscometer offers high spatiotemporal resolution for measuring intracellular viscosity. This tool reveals viscosity differences within cells, aiding biological process and disease research.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Nanotechnology

Background:

  • Accurate measurement of single-cell viscosity is crucial for understanding cellular processes.
  • Existing methods for single-cell viscosity measurement lack sufficient spatiotemporal resolution.
  • A gap exists in the available single-cell nanotools for viscosity analysis.

Purpose of the Study:

  • To develop a high spatiotemporal resolution iontronic single-cell viscometer.
  • To enable sensitive monitoring of intracellular viscosity variations.
  • To provide an accessible tool for single-cell biophysical studies.

Main Methods:

  • Utilized a patch clamp integrated with double-barreled nanopores (32 nm septum).
  • Employed reversible electroosmotic manipulation of fluid between nanopores.
  • Monitored viscosity changes via sensitive ionic responses.

Main Results:

  • Demonstrated high spatiotemporal resolution for single-cell viscosity measurement.
  • Observed intracellular viscosity variations, with the near-nuclear region being the most viscous.
  • Found medium viscosities less deviated than those of lysosomes and mitochondria.

Conclusions:

  • The developed iontronic viscometer is an accessible and effective single-cell nanotool.
  • This technology enhances the understanding of intracellular mechanics and heterogeneity.
  • Provides new insights into cellular responses and disease pathologies.