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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Dissolution of struvite stones with ascorbic acid.

Satoshi Yoshikawa1

  • 1Department of Emergency and General Internal Medicine, Rakuwakai Marutamachi Hospital, 9-7 Jurakumawari-Matsushita-cho, Nakagyo-ku, 604-8401, Kyoto, Japan.

Urology Case Reports
|January 6, 2025
PubMed
Summary
This summary is machine-generated.

This case report shows ascorbic acid can help dissolve struvite stones by lowering urine pH. Dual-energy CT imaging aids in diagnosing and monitoring stone composition and treatment effectiveness.

Keywords:
Dual-energy CTascorbic acidcranberry juicekidney stonestruviteureteral stoneurolithiasis

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Area of Science:

  • Nephrology
  • Urology
  • Biochemistry

Background:

  • Recurrent urinary tract infections and obstructive pyelonephritis can be caused by Proteus mirabilis leading to struvite stones.
  • Struvite stones often require intervention beyond standard antibiotic therapy due to their composition and potential for growth.

Observation:

  • An elderly male patient presented with recurrent urinary tract infections and obstructive pyelonephritis with growing struvite stones despite antibiotic treatment.
  • Dual-energy CT imaging was utilized to accurately characterize the stone composition.

Findings:

  • Ascorbic acid administration was initiated to lower urine pH, promoting struvite stone dissolution.
  • The use of ascorbic acid demonstrated an acceleration in the dissolution of struvite stones.
  • Dual-energy CT proved valuable for both the initial diagnosis of stone composition and subsequent monitoring during treatment.

Implications:

  • Ascorbic acid represents a viable therapeutic option for accelerating struvite stone dissolution.
  • Dual-energy CT is a key imaging modality for diagnosing, monitoring, and guiding treatment for struvite urolithiasis.
  • This case underscores the importance of considering adjunctive therapies for complex stone cases resistant to conventional treatment.