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Anti-MDA5 Positive Juvenile Dermatomyositis With Macrophage Activation Syndrome: A Case Report
Alaa S Mehair1, Miroslav Harjacek1
1Pediatric Medicine, Tawam Hospital, Abu Dhabi, ARE.
Juvenile dermatomyositis (JDM) can lead to macrophage activation syndrome (MAS), a rare but serious complication. This case highlights MAS in a JDM patient with anti-MDA5 antibodies, emphasizing the need for clinical awareness.
Area of Science:
- Rheumatology
- Pediatrics
- Immunology
Background:
- Juvenile dermatomyositis (JDM) is an autoimmune disease causing muscle inflammation and weakness.
- Macrophage activation syndrome (MAS) is a rare, severe complication of JDM.
- Anti-MDA5 antibody-positive JDM is a rare, often fatal subtype associated with lung disease.
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