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Related Experiment Video

Updated: May 12, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

TIM3 in COVID-19; A potential hallmark?

Mohammad Reza Zamani^1,2, Pavel Šácha²

¹Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.

|January 6, 2025

Summary

This summary is machine-generated.

This review explores the role of TIM3, an immune checkpoint, in COVID-19 patients. Understanding TIM3

Keywords:

Biomarker COVID-19 Immune checkpoint Infection TIM3 Virus

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Area of Science:

Immunology
Virology
Infectious Diseases

Background:

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents with diverse symptoms and is linked to immune dysfunction.
Immune system abnormalities, including T-cell dysfunction and cytokine imbalances, are associated with severe COVID-19 outcomes.
Inhibitory immune checkpoints play a regulatory role in the immune response during SARS-CoV-2 infection.

Purpose of the Study:

To review existing literature on the role of the T-cell immunoglobulin and mucin-domain containing-3 (TIM3) in COVID-19 patients.
To highlight TIM3 as a less-characterized immune checkpoint relevant to COVID-19 pathogenesis and outcomes.

Main Methods:

Systematic review of published studies investigating TIM3 expression and function in the context of COVID-19.
Analysis of findings related to immune checkpoint regulation in SARS-CoV-2 infection.

Main Results:

Studies suggest a link between immune checkpoint dysregulation and adverse clinical outcomes in COVID-19.
Evidence points to TIM3's involvement in modulating T-cell responses during SARS-CoV-2 infection, though not fully elucidated.
Specific findings on TIM3's impact on cytokine profiles and mortality risk in COVID-19 patients are being gathered.

Conclusions:

TIM3 represents a potential therapeutic target for modulating immune responses in severe COVID-19.
Further research is needed to fully understand the complex role of TIM3 in COVID-19 pathogenesis and patient outcomes.
Investigating TIM3 could offer new insights into immune dysfunction and mortality associated with SARS-CoV-2.