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Effect of abdominal aortic calcification on long-term outcomes after the first liver resection in very old patients with hepatocellular carcinoma

  • 0Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.
Annals of Gastroenterological Surgery +

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January 6, 2025

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January 6, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Abdominal aortic calcification is linked to higher recurrence rates and poorer survival in elderly patients undergoing liver cancer surgery. This finding highlights its importance in predicting outcomes for hepatocellular carcinoma patients over 80.

Area Of Science

  • Oncology
  • Cardiovascular Medicine
  • Geriatric Surgery

Background

  • Abdominal aortic calcification (AAC) is a known predictor of poor survival after liver cancer surgery.
  • Its impact on cancer-specific prognosis in very elderly patients with comorbidities is not well understood.

Purpose Of The Study

  • To investigate the association between abdominal aortic calcification and recurrence in patients aged over 80 undergoing hepatectomy for hepatocellular carcinoma (HCC).
  • To evaluate the effect of AAC on recurrence-free survival in this specific elderly cohort.

Main Methods

  • Retrospective analysis of 128 patients (≥80 years) with HCC who underwent liver resection.
  • Patients were stratified into high and low abdominal aortic calcification groups.
  • Primary endpoints included cumulative recurrence rate and recurrence-free survival.

Main Results

  • Higher AAC was significantly associated with increased cumulative recurrence rates.
  • Patients with high AAC exhibited significantly lower recurrence-free survival.
  • Multivariate analysis identified high AAC as an independent predictor for recurrent HCC and poor cancer-specific survival.

Conclusions

  • Abdominal aortic calcification score is a significant independent predictor of recurrence and survival in very elderly patients with HCC.
  • AAC assessment may aid in risk stratification and personalized treatment strategies for this population.

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