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Updated: May 7, 2025
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
The role of miR-155 in cardiovascular diseases: Potential diagnostic and therapeutic targets
Rui-Lin Zhang1, Wei-Ming Wang1,2,3,4, Ji-Qiang Li1
1Department of Vascular Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Insights
MicroRNAs (miRNAs), specifically miR-155, play a key role in cardiovascular diseases (CVDs). This review highlights miR-155's potential as a diagnostic biomarker and therapeutic target for various heart conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Medicine
Background:
- Cardiovascular diseases (CVDs) pose a significant global health challenge.
- MicroRNAs (miRNAs) are crucial posttranscriptional regulators in disease pathogenesis.
- miR-155 shows altered expression in various CVDs and contributes to arterial disorders.
Purpose of the Study:
- To systematically review the role of miR-155 in cardiovascular diseases.
- To explore miR-155's potential as a diagnostic biomarker and therapeutic target.
- To synthesize evidence on miR-155's regulatory functions in CVD pathology.
Main Methods:
- Systematic literature review.
- Analysis of studies investigating miR-155 expression and function in CVD models and patients.
- Synthesis of evidence on miR-155's impact on atherosclerosis, heart failure, and other cardiovascular conditions.
Main Results:
- miR-155 is differentially expressed across various cardiovascular diseases.
- miR-155 modulates key genes and pathological processes in CVD, including atherosclerosis, hypertension, and heart failure.
- Evidence supports miR-155's involvement in myocardial hypertrophy and oxidative stress.
Conclusions:
- miR-155 is a significant regulator in cardiovascular disease development and progression.
- miR-155 holds promise as a diagnostic biomarker for CVD.
- Targeting miR-155 presents a potential therapeutic strategy in cardiovascular medicine.
Abstract:
Cardiovascular diseases (CVDs), such as atherosclerotic cardiovascular diseases, heart failure (HF), and acute coronary syndrome, represent a significant threat to global health and impose considerable socioeconomic burdens. The intricate pathogenesis of CVD involves various regulatory mechanisms, among which microRNAs (miRNAs) have emerged as critical posttranscriptional regulators. In particular, miR-155 has demonstrated differential expression patterns across a spectrum of CVD and is implicated in the etiology and progression of arterial disorders. This systematic review synthesizes current evidence on the multifaceted roles of miR-155 in the modulation of genes and pathological processes associated with CVD. We delineate the potential of miR-155 as a diagnostic biomarker and therapeutic target, highlighting its significant regulatory influence on conditions such as atherosclerosis, aneurysm, hypertension, HF, myocardial hypertrophy, and oxidative stress. Our analysis underscores the transformative potential of miR-155 as a target for intervention in cardiovascular medicine, warranting further investigation into its clinical applicability.
