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[Effect of naphthoquinones and tocopherols on the changes in mitochondrial volume]

V A Lider, N G Bogdanov

    Ukrainskii Biokhimicheskii Zhurnal (1978)
    |January 1, 1985
    PubMed

    Insights

    Long-term vitamin E and K deficiency impairs mitochondrial volume regulation in mice. Supplementation with vitamin K partially restored mitochondrial function, suggesting a role in maintaining cellular integrity.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Mitochondrial Physiology

    Context:

    • Mitochondria are vital organelles responsible for cellular energy production and volume regulation.
    • Nutritional deficiencies, particularly in fat-soluble vitamins like tocopherols (vitamin E) and naphthoquinones (vitamin K), can impact cellular function.
    • Understanding the effects of hypovitaminosis on mitochondrial dynamics is crucial for metabolic health.

    Purpose:

    • To investigate the impact of chronic tocopherol and naphthoquinone deficiency on mitochondrial volume regulation in vivo.
    • To assess the functional capacity of mitochondria to regulate volume following ADP stimulation in hypovitaminotic mice.
    • To evaluate the potential protective effect of vitamin K1 supplementation on mitochondrial volume changes induced by acetone treatment.

    Summary:

    • Chronic deficiency of natural tocopherols and naphthoquinones in mice led to altered mitochondrial volume in liver, myocardium, and skeletal muscles.
    • Mitochondria from deficient mice showed impaired volume regulation upon ADP addition, indicating a loss of active control.
    • Acetone treatment caused significant mitochondrial swelling, which was partially mitigated by the addition of vitamin K1.

    Impact:

    • This study highlights the critical role of tocopherols and naphthoquinones in maintaining mitochondrial structural integrity and functional regulation.
    • The findings suggest that hypovitaminosis E and K can compromise cellular energy metabolism by impairing mitochondrial volume control.
    • Vitamin K1 may play a protective role against mitochondrial dysfunction induced by certain chemical agents, offering potential therapeutic insights.

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