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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Unveiling the Diverse Principles for Developing Sprayable Hydrogels for Biomedical Applications.

So-Jin Park1,2, Taek Hwang1,3, SeongHoon Jo1

  • 1Center of Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

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Summary

Sprayable hydrogels offer versatile, minimally invasive biomedical solutions. This review explores their in situ gelation, shear-thinning, and thermoresponsive properties for advanced wound care, drug delivery, and tissue engineering.

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Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Sprayable hydrogels represent a significant advancement in biomedical technology.
  • Their ability to form gels in situ allows for efficient and minimally invasive application on complex tissue surfaces.

Purpose of the Study:

  • To review the fundamental principles and recent advancements in sprayable hydrogel technology.
  • To highlight the engineering strategies for optimizing sprayable hydrogels in clinical applications.

Main Methods:

  • Review of scientific literature focusing on sprayable hydrogels, particularly advancements since 2020.
  • Analysis of critical mechanisms including in situ cross-linking, shear-thinning, and thermoresponsive behavior.

Main Results:

  • Sprayable hydrogels enable localized and sustained release of therapeutics, crucial for wound care, drug delivery, and tissue engineering.
  • Customizable formulations incorporating bioactive compounds like growth factors and antibiotics enhance targeted treatment outcomes.

Conclusions:

  • Sprayable hydrogels are a versatile platform with significant potential in various medical fields.
  • Understanding their core mechanisms and design strategies is key to advancing their application in modern medicine.