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Updated: Jun 3, 2025

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

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Published on: November 10, 2023

Prognostic Value of Surgical Resection for Non-small-cell Lung Cancer Patients Comorbid With Minimal Pleural

Haibo Wang^1,2, Tao Lu³, Xinlong Zheng^1,2

¹Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.

Cancer Control : Journal of the Moffitt Cancer Center

|January 6, 2025

Summary

Minimal pleural effusion (PE) in operable non-small cell lung cancer (NSCLC) is rarely malignant. Surgical intervention for NSCLC patients with minimal PE and no metastasis significantly improves overall survival compared to non-surgical approaches.

Keywords:

minimal pleural effusion non-small cell lung cancer prognosis surgical resection

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Area of Science:

Thoracic Surgery
Oncology
Pulmonology

Background:

The prognostic impact of minimal pleural effusion (PE) in operable non-small cell lung cancer (NSCLC) is not well-defined.
Minimal PE on imaging in NSCLC patients often presents diagnostic challenges regarding malignancy.

Purpose of the Study:

To clarify the incidence and prognostic significance of minimal PE in operable NSCLC.
To evaluate the efficacy of surgical intervention in NSCLC patients with minimal PE.

Main Methods:

Retrospective analysis of clinical and prognostic data from operable NSCLC patients with minimal PE.
Comparison of outcomes between a surgical cohort (81 cases) and a non-surgical cohort (10 cases).
Overall survival (OS) analyzed using Kaplan-Meier curves and Cox regression.

Main Results:

Malignant PE was found to be rare in this patient group.
The surgical cohort demonstrated significantly longer median OS (59.8 months) than the non-surgical cohort (20.37 months).
Surgical treatment was identified as an independent prognostic factor for improved OS.

Conclusions:

Minimal PE in operable NSCLC without metastasis or direct pleural invasion is infrequently malignant.
Surgery may represent the optimal treatment strategy for selected NSCLC patients presenting with minimal PE.