Pd(OAc)2-Catalyzed Approach to Phenanthridin-6(5H)-one Skeletons
Ye Li1, Dong-Wei Wang1, Jian-Quan Liu1
1School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Abstract:
Herein, we present a Pd(OAc)2/Dppp-catalyzed synthesis of 4-arylphenanthridinones from 2-bromobenzamides and iodobenzene, which undergoes successive Ullman cross-coupling, C-H activation, and oxidative coupling dehydrogenation process. The presented methods offer an adaptable and modular synthesis route for efficiently producing a wide array of valuable phenanthridiones, demonstrating exceptional compatibility with functional groups. Alternatively, a 1:1 cross-coupling reaction utilizing an intramolecular norbornene moiety as the ligand resulted in phenanthridinones through N-arylation and C-H activation.
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