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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Techniques to Induce and Quantify Cellular Senescence
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Cellular senescence in the cancer microenvironment.

Satoru Meguro1,2, Makoto Nakanishi1

  • 1Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108-8639, Tokyo, Japan.

Journal of Biochemistry
|January 6, 2025
PubMed
Summary

Cellular senescence, a state of permanent cell arrest, contributes to age-related diseases and cancer progression. Senotherapeutics, targeting these senescent cells, show promise as a novel cancer therapy.

Keywords:
cancercancer-associated fibroblastcellular senescencesenescent cellsenotherapeutics

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A Sensitive Method to Quantify Senescent Cancer Cells
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Area of Science:

  • Gerontology and Oncology
  • Cell Biology and Cancer Research

Background:

  • Increasing prevalence of age-related diseases, including cancer, in aging populations.
  • Cellular senescence, characterized by permanent cell cycle arrest, contributes to tissue aging and inflammation.
  • Senescent cells, particularly cancer-associated fibroblasts, impact the tumor microenvironment and cancer progression.

Purpose of the Study:

  • To explore the complex and heterogeneous association between cellular senescence and cancer.
  • To review the emerging role of senescent cells and their secretory phenotype (SASP) in cancer development.
  • To highlight the potential of senotherapeutics as a novel cancer treatment strategy.

Main Methods:

  • Review of current scientific literature on cellular senescence and cancer.
  • Analysis of the impact of senescence-associated secretory phenotype (SASP) on the tumor microenvironment.
  • Examination of preclinical and clinical data on senotherapeutics.

Main Results:

  • Cellular senescence plays a multifaceted role in cancer, with mechanisms still under investigation.
  • Accumulated senescent cells and their SASP create an inflammatory tumor microenvironment.
  • Senotherapeutics have demonstrated efficacy in preclinical cancer models and early clinical trials.

Conclusions:

  • Cellular senescence is a significant factor in cancer progression and the tumor microenvironment.
  • Targeting senescent cells with senotherapeutics represents a promising novel therapeutic avenue for cancer.
  • Further research into senotherapeutics is expected to advance their development as a cancer therapy.