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Updated: Jun 3, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Management strategies for patients with chronic lymphocytic leukaemia harbouring complex karyotype
Andrea Serafin1, Valeria Ruocco1, Alessandro Cellini1
1Hematology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy.
Abstract:
Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease characterised by the uncontrolled proliferation of mature lymphocytes. A subset of CLL patients harbouring complex karyotype (CK) presents with poor prognosis and limited treatment options. This review aims to discuss the current understanding of such patient subset, including its molecular landscape, diagnostic approaches, treatment modalities and emerging therapies. Furthermore, it outlines strategies for personalised management to improve clinical outcomes in this challenging patient population.
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