Related Experiment Video

Updated: Jun 3, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

85.8K

Rarity of Congenital Adrenal Hyperplasia in Children Born Very Preterm: Possible Mechanism and Implication for

Asmahane Ladjouze1,2, Yasmina Ouarezki3,4, Adel Djermane3,4

  • 1Department of Paediatrics A, Centre Hospitalo-Universitaire Béni-Messous, Algiers, Algeria, a.ladjouze@univ-alger.dz.

Hormone Research in Paediatrics
|January 6, 2025
PubMed

Insights

Newborn screening for congenital adrenal hyperplasia (CAH) is crucial in Algeria to balance sex ratios. The study suggests restricting screening to infants born after 32 weeks gestation may improve cost-effectiveness.

Area of Science:

  • Endocrinology
  • Genetics
  • Neonatal Health

Background:

  • Congenital adrenal hyperplasia (CAH) screening via 17-hydroxyprogesterone aims to prevent deaths, reduce salt-wasting severity, and correct sex assignment in virilized females.
  • Current screening is common in high-income nations but has low predictive value for preterm infants and is largely absent in low- and middle-income countries.

Purpose of the Study:

  • To assess the justification of implementing CAH newborn screening in Algeria.
  • To evaluate the prevalence of premature birth and the sex ratio in Algerian infants diagnosed with CAH.

Main Methods:

  • Analysis of a cohort of 299 singleton Algerian infants diagnosed with CAH.
  • Assessment of gestational age at birth and the sex ratio among affected infants.

Main Results:

  • Only 4% of CAH infants were born preterm (before 37 weeks), lower than the general Algerian population rate (14.3%).
  • No infants were born before 34 weeks gestation.
  • The salt-wasting (SW) form of CAH was diagnosed in 93 boys and 139 girls.

Conclusions:

  • The rarity of very preterm birth in Algerian CAH infants may be linked to fetal hormonal production (high 17-hydroxyprogesterone, low cortisol).
  • Newborn screening for CAH is recommended for Algeria to equalize the sex ratio.
  • Screening could be limited to neonates born after 32 weeks gestation to enhance cost-effectiveness.
Abstract

Keywords:
17-HydroxyprogesteroneCongenital adrenal hyperplasiaNewborn screeningPrematurity

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.3K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.5K

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.3K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
126
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
5.6K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
36
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K