Related Experiment Video

Updated: Jun 3, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.3K

Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs

Bahaa Ibrahim Saeed1, Abhinav Kumar2, Enwa Felix Oghenemaro3

  • 1Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq.

Experimental Cell Research
|January 6, 2025
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate cell functions by modulating cyclin-dependent kinase inhibitors (CDKIs). While lncRNAs are linked to diseases, their impact on cell proliferation and CDKI modulation remains uncertain.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • The human genome is extensively transcribed, but only a small fraction of the transcriptome yields proteins.
  • The majority of transcripts are non-coding RNAs, including long non-coding RNAs (lncRNAs) longer than 200 bases.
  • lncRNAs perform diverse functions, including gene transcription control, DNA topology, nucleosome organization, and organelle development.

Purpose of the Study:

  • To investigate the role of lncRNAs in regulating the levels and activities of cyclin-dependent kinase inhibitors (CDKIs).
  • To explore the connection between lncRNA, CDKI regulation, and cellular function, particularly in the context of disease.

Main Methods:

  • Literature review and analysis of existing evidence on lncRNA function.
  • Examination of the regulatory mechanisms involving lncRNAs and cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs).

Main Results:

  • lncRNAs are implicated in regulating CDKIs, which are crucial for controlling the cell cycle via interactions with CDKs.
  • lncRNAs are associated with various diseases, utilizing CDKI regulation to influence cellular processes.
  • Despite existing evidence, the precise impact of lncRNAs on cell proliferation and CDKI modulation requires further elucidation.

Conclusions:

  • lncRNAs play a significant role in cellular regulation through their interaction with CDKIs.
  • The dysregulation of lncRNAs and CDKIs is linked to pathological conditions.
  • Further research is needed to fully understand the extent of lncRNA influence on cell proliferation and CDKI activity.
Keywords:
CDKsCancerCell growthCyclinsLncRNA

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.5K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.0K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.3K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.6K