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Novel therapeutic targets for cardiorenal syndrome

Mansi Vinodkumar Trivedi1, Hemant R Jadhav1, Anil Bhanudas Gaikwad1

  • 1Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.

Drug Discovery Today
|January 6, 2025
PubMed

Insights

Cardiorenal syndrome involves interdependent heart and kidney dysfunction. New therapeutic targets are crucial due to limitations in current cardiorenal syndrome treatments.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomedical Science

Background:

  • Cardiorenal syndrome (CRS) is a complex condition characterized by the interdependent dysfunction of the heart and kidneys.
  • Pathophysiological mechanisms include renin-angiotensin-aldosterone-system (RAAS) activation, inflammation, fibrosis, and oxidative stress, leading to organ damage.

Purpose of the Study:

  • To review the limitations of current cardiorenal syndrome therapies.
  • To highlight the urgent need for novel therapeutic targets in CRS management.

Main Methods:

  • Literature review of cardiorenal syndrome pathogenesis and treatment.
  • Identification and discussion of emerging therapeutic targets.

Main Results:

  • Current therapies for cardiorenal syndrome, including RAAS inhibitors and diuretics, exhibit significant limitations such as diuretic resistance.
  • Emerging targets like Klotho, SOX9, RIPK3, BAIBA, and TSP-1 show potential for novel therapeutic strategies in CRS.

Conclusions:

  • There is a critical need for innovative therapeutic approaches to address cardiorenal syndrome.
  • Exploring novel targets involved in CRS pathogenesis offers promising avenues for improved patient outcomes.

Keywords:
BAIBAHeartRIPK3SOX9cardiorenal syndromekidneynovel therapeutic targets

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