Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes

Nanocatalytic medicine offers a novel solution to address the issues of low efficacy, potential side effects, and the development of drug resistance associated with traditional therapies. Therefore, developing highly efficient and durable nanozymes is of great significance for treating diseases related to oxidative stress. In recent years, prussian blue nanoparticles (PBNPs) have been demonstrated to possess multiple enzyme-like catalytic activities and are thus referred to as prussian blue nanozymes (PBNZs). Their excellent biocompatibility and biodegradability make PBNZs promising candidates as biomedical materials. Due to their remarkable catalytic activities, PBNZs have shown great potential in various biomedical applications, such as heavy metal detoxification, antioxidative damage, and anticancer therapies. This paper systematically summarizes the Synthetic strategies of PBNZs, analyzes the regulatory factors of their catalytic performance, and highlights the corresponding modulation methods. Furthermore, the biomedical applications of PBNZs are also reviewed. This study aims to provide researchers with insights and inspirations for the design and preparation of high-performance PBNZs.