Related Experiment Video
Updated: Jun 22, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Knot-knot chronicles: unveiling the G-quadruplexes
Himanshi Sharma1, Rohini Garg1
1Centre of Excellence in Epigenetics, Department of Life Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, India.
Abstract:
G-quadruplex structures (GQSes) are the intricate molecular knots or marvels that play diverse roles in various cellular processes, such as replication, transcription, and translation, which regulate gene expression. Even though GQSes can be found throughout the genome, they are more prevalent in certain genomic regions like promoters and 5'-UTRs. This review discusses the functionality of GQSes across various regions of the genome and draws attention to the intriguing world of DNA and RNA GQSes. We highlight the uniqueness and similarities of GQSes in DNA and RNA. The functional roles of various proteins that interact with GQSes are also discussed. In addition, the role of GQSes in the context of plant development has been elaborated. The approaches for detecting GQSes using different methods and their influence in regulating gene regulation are also described. We provide insights into how GQSes can be used as potential game changers in plant biotechnology by utilizing them as regulatory switches to control various aspects of transcriptional and post-transcriptional processes depending on the arrangement of GQSes.
Related Concept Videos
RNA Structure
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
DNA Base Pairing
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...
RNA Structure
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...

