Related Experiment Video
Updated: May 7, 2025

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Innate versus adoptive competence: the controlled distribution of signalling receptors extends the concept of
Jessica L Bamsey1, Lucy Brunt1, Steffen Scholpp1
1Living Systems Institute, University of Exeter, Exeter, UK.
Abstract:
Cellular communication through the dissemination of signal molecules is vital for tissue organisation and homeostasis. The mechanisms of signal spreading can include binding-protein-assisted transport, long membrane protrusions known as cytonemes, and exovesicles. Recent research indicates that cytonemes and exovesicles can not only transport ligands but also facilitate the regulated distribution of receptors, thereby enabling signal transduction in cells lacking endogenous receptors. This mechanism allows non-responsive cells to temporarily acquire the ability to respond to specific ligands. This review explores our understanding of ligand and receptor dispersal, offering fresh insights into the fundamental concept of cellular competence. Notably, these findings may have significant implications for diseases and their associated therapeutic targets, highlighting the urgency and importance of this research area.
More Related Videos
07:34The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
Published on: February 16, 2017
07:18Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
Published on: October 27, 2023
Related Concept Videos
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Signal Transduction: Overview
Typically, signal transduction involves three...
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...
Internal Receptors
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...