Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The variable hyponatremic response to hyperglycemia.

S M Moran, R L Jamison

The Western Journal of Medicine

|January 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Warfarin anticoagulation: a survey of patients' knowledge of their treatment.

Irish journal of medical science·2011

Same author

Mop3 is an essential component of the master circadian pacemaker in mammals.

Cell·2001

Same author

The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000

Same author

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

Gene expression·1998

Same author

Hyponatremia: a re-examination.

Current opinion in nephrology and hypertension·1997

Same author

Low-flow (1 l/min) sevoflurane: is it safe?

Anesthesiology·1997

Same journal

Does daily use of sunscreen or beta-carotene supplements prevent skin cancer in healthy adults?

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

Same journal

[Not Available].

The Western journal of medicine·2008

See all related articles

High blood glucose levels (hyperglycemia) can affect sodium levels in the blood. This study suggests the effect of hyperglycemia on plasma sodium concentration is variable, not fixed, depending on body water and solute balance.

Area of Science:

Nephrology
Endocrinology
Internal Medicine

Background:

Hyperglycemia is commonly associated with decreased plasma sodium concentration (hyponatremia).
Previous theoretical models proposed a consistent, invariant relationship between glucose levels and sodium levels.

Purpose of the Study:

To challenge the concept of an invariant hyponatremic response to hyperglycemia.
To propose a more variable model for the relationship between plasma sodium and glucose concentrations.

Main Methods:

Formulation of a model incorporating key physiological factors.
Analysis of the interplay between body water and solute distribution.
Consideration of the relationship between extracellular glucose gain and intracellular solute loss.

Related Experiment Videos

Inclusion of solute and water intake and loss dynamics.

Main Results:

The change in plasma sodium concentration during hyperglycemia is not constant.
The response is influenced by the distribution of total body water and solutes.
The balance of solute and water intake and loss significantly impacts the sodium concentration.

Conclusions:

The relationship between plasma sodium and glucose concentrations is variable.
A comprehensive model accounting for water and solute dynamics provides a more accurate representation of hyperglycemia's effect on sodium levels.