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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Electro-polymerization of modified carbon paste sensor for detecting azithromycin.

Salma Mamdouh¹, M Shehata¹, A M Fekry¹

¹Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Scientific Reports

|January 6, 2025

Summary

This summary is machine-generated.

Researchers developed a poly-threonine carbon paste electrode (PTCPE) for sensitive azithromycin (AM) detection. This novel sensor offers accurate quantification of AM in pharmaceutical drugs.

Keywords:

Antiviral Azithromycin COVID-19 Electro-polymerization L-Threonine

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Published on: September 19, 2017

Area of Science:

Electrochemistry
Analytical Chemistry
Materials Science

Background:

Azithromycin (AM) is a crucial antibiotic in pandemic treatments.
Effective detection methods are vital for pharmaceutical quality control.

Purpose of the Study:

To develop a sensitive and reliable electrochemical sensor for azithromycin detection.
To utilize poly-threonine (PT) modification for enhanced electrode performance.

Main Methods:

Fabrication of a modified carbon paste electrode (CPE) with poly-threonine (PT).
Electrochemical characterization using Cyclic Voltammetry (CV) and electrochemical impedance spectroscopy (EIS).
Optimization of detection parameters including pH, scan rate, and accumulation time.

Main Results:

The poly-threonine carbon paste electrode (PTCPE) demonstrated high sensitivity for azithromycin oxidation.
A wide working pH range (5.0-10.0) was established in phosphate buffer solution (PBS).
Achieved a low detection limit of 0.32 µM and quantification limit of 1.07 µM at pH 7.4.

Conclusions:

The developed PTCPE provides a sensitive and consistent platform for azithromycin detection.
This method is suitable for analyzing azithromycin in pharmaceutical formulations.
The poly-threonine modification enhances the electrochemical sensing capabilities for AM.