Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Metabolic aspects of multiple sclerosis].

I S Neu

    Wiener Medizinische Wochenschrift (1946)
    |January 31, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Multiple sclerosis (MS) may stem from disrupted lipid metabolism, specifically reduced polyunsaturated fatty acids (PUFA) and essential fatty acids (EFA). This suggests potential issues with EFA utilization impacting cell membranes and immune responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Leukotrienes in patients with clinically active multiple sclerosis.

    Acta neurologica Scandinavica·2002
    Same author

    [Differential diagnosis and therapy of headache in general practice. Anamnesis is the alpha and omega].

    MMW Fortschritte der Medizin·2001
    Same author

    Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis.

    Arzneimittel-Forschung·1998
    Same author

    [Treatment of post-traumatic headaches. Recommendations of the German Migraine and Headache Society].

    Medizinische Monatsschrift fur Pharmazeuten·1998
    Same author

    [Intraspinal manifestation of cysticercosis--Cysticercus racemosus. A case report and review of the literature].

    Der Nervenarzt·1994
    Same author

    Multifocal inflammatory leukencephalopathy caused by adjuvant therapy with 5-fluorouracil and levamisole after resection for an adenocarcinoma of the colon.

    Acta neurologica Scandinavica·1993

    Area of Science:

    • Biochemistry
    • Immunology
    • Neuroscience

    Background:

    • Multiple sclerosis (MS) is a complex neurological disorder.
    • A potential predisposing factor involves disturbances in lipid and fatty acid metabolism.

    Purpose of the Study:

    • To investigate the role of lipid metabolism disturbances in the pathogenesis of MS.
    • To explore the utilization of essential fatty acids (EFA) in MS patients.

    Main Methods:

    • Analysis of polyunsaturated fatty acids (PUFA) and EFA concentrations in plasma, blood cells, CSF, and brain white matter.
    • Lipid-chemical and lipolytic enzymological studies to assess fatty acid metabolism.

    Main Results:

    • Decreased concentrations of PUFA and EFA observed in various tissues of MS patients.

    Related Experiment Videos

  • Disturbed EFA absorption was excluded, suggesting issues with utilization.
  • Potential defects in fatty acid elongation and phospholipase A1 activation identified.
  • A generalized defect in biological membranes, particularly myelin and platelets, is proposed.

    • Conclusions:

    • Metabolic and immunological factors may contribute to MS pathogenesis.
    • Altered lipid metabolism, especially EFA utilization, could predispose individuals to MS.
    • Prostaglandins (PGs) may play a role due to their fatty acid precursors and immune influence.
    • Further research is needed for a comprehensive biochemical-immunological model of MS and improved diagnostics.