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[Visual and acoustic evoked potentials in multiple sclerosis].

B Kofler

    Wiener Medizinische Wochenschrift (1946)
    |January 31, 1985
    PubMed
    Summary
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    Evoked potentials, including visual evoked potential (VEP) and brainstem auditory evoked potential (BAEP), effectively detect early multiple sclerosis (MS) lesions. These neurophysiological techniques reveal silent lesions in MS patients, outperforming CT scans for brainstem pathology.

    Area of Science:

    • Neurophysiology
    • Neurology
    • Medical Imaging

    Context:

    • Multiple sclerosis (MS) research focuses on early lesion detection using sensitive neurophysiological techniques.
    • Evoked potentials have proven valuable in identifying clinically silent lesions, particularly in the optic nerve and brainstem.
    • The brainstem is a common site for demyelination in MS, often missed by traditional methods.

    Purpose:

    • To evaluate the diagnostic utility of visual evoked potentials (VEP) and brainstem auditory evoked potentials (BAEP) in multiple sclerosis (MS) patients.
    • To assess the ability of VEP and BAEP to detect subclinical lesions in various MS patient groups.
    • To compare the sensitivity of evoked potentials with computer tomography (CT) in identifying brainstem pathology.

    Summary:

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  • The study recorded VEP in 177 MS patients, finding abnormal latencies in 86%, 46%, and 34% of definite, probable, and possible MS cases, respectively. 44% of patients without optic nerve symptoms showed delayed VEPs.
  • BAEP analysis revealed pathological results in 74%, 60%, and 48% of definite, probable, and possible MS patients. Notably, 50% of asymptomatic patients had abnormal BAEPs.
  • Computer tomography detected brainstem pathology in only 10% of MS patients, highlighting the superior sensitivity of BAEP for this region.

    • Impact:

    • VEP and BAEP are highly sensitive tools for detecting early and subclinical lesions in multiple sclerosis.
    • These neurophysiological methods offer superior detection rates for brainstem lesions compared to CT scans.
    • The findings support the integration of evoked potentials into routine MS diagnostics for improved patient management and monitoring.