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[Clinical findings in multiple sclerosis].

G Ladurner, S Fuchs, E Körner

    Wiener Medizinische Wochenschrift (1946)
    |January 31, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    This study followed 170 multiple sclerosis (MS) patients for nearly 9 years, observing initial symptoms and disease progression. Findings reveal a spectrum of MS presentations, including benign forms and varying symptomology over time.

    Area of Science:

    • Neurology
    • Clinical Medicine

    Context:

    • Investigated the long-term clinical course of 170 patients diagnosed with multiple sclerosis (MS).
    • Examined the evolution of symptoms and neurological status over an average of 8.8 years between initial and final interviews.

    Purpose:

    • To characterize the clinical spectrum and progression patterns in a cohort of multiple sclerosis patients.
    • To identify initial and evolving symptomatology, including atypical presentations and psychiatric manifestations.

    Summary:

    • The average interval between the first and last clinical interview for 170 multiple sclerosis patients was 8.8 years.
    • Initial symptoms commonly included sensory disturbances and cranial nerve paresis; 6% presented with uncharacteristic symptoms and 6% with psychiatric symptoms.
    • By the last investigation, psychiatric symptoms decreased to 2% and uncharacteristic symptoms to 4%, with 9% showing normal neurological status, indicating diverse disease trajectories and potential for benign forms.

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    Impact:

    • Highlights the heterogeneity of multiple sclerosis, encompassing typical, atypical, and benign disease forms.
    • Provides insights into the dynamic nature of MS symptomatology over an extended clinical observation period.
    • Contributes to a better understanding of long-term multiple sclerosis patient management and prognosis.