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Context-dependent decision-making in the primate hippocampal-prefrontal circuit.

Thomas W Elston1,2, Joni D Wallis3

  • 1Department of Neuroscience, University of California, Berkeley, Berkeley, CA, USA. elston@utexas.edu.

Nature Neuroscience
|January 6, 2025
PubMed
Summary

The hippocampus (HPC) and orbitofrontal cortex (OFC) use distinct neural signals for flexible decision-making. The HPC encodes context, communicating it to the OFC via theta synchronization for state-dependent value representation.

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