First Experience With a Novel Self-Expandable Valve for Mitral Annular Calcification Guided by Three-Dimensional...

Area of Science:

• Cardiology
• Interventional Cardiology
• Medical Device Technology

Background:

• Severe mitral annular calcification (MAC) poses significant risks for traditional open-heart surgery.
• Transcatheter mitral valve replacement (TMVR) is an emerging alternative for high-risk patients.
• Challenges remain in device selection and procedural guidance for TMVR in complex cases like severe MAC.

Purpose of the Study:

• To present the first case of TMVR using the novel Mi-thos system in a patient with severe MAC.
• To evaluate the feasibility and safety of the Mi-thos system via a transapical approach.
• To demonstrate the utility of patient-specific 3D printed models in guiding TMVR procedures.

Main Methods:

• A 67-year-old high-risk female patient with severe MAC and mitral stenosis underwent TMVR.
• The novel Mi-thos system was deployed via a transapical approach.
• A patient-specific 3D printed model, created from CT angiography data, was used for preprocedural planning and intraoperative guidance.

Main Results:

• The TMVR procedure using the Mi-thos system was successfully completed.
• The use of a 3D printed model facilitated procedural planning and execution.
• The patient experienced symptomatic improvement following the intervention.

Conclusions:

• The Mi-thos system, guided by a patient-specific 3D printed model, appears to be a feasible and safe option for TMVR in high-risk patients with severe MAC.
• This case highlights the potential of personalized 3D modeling to enhance outcomes in complex transcatheter valve interventions.
• Further research is warranted to confirm the long-term efficacy and safety of this approach.