Related Experiment Video
Updated: Jun 3, 2025

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
Published on: February 15, 2019
Effect of aspiration during intramuscular injection on the occurrence of adverse effects in adults: a systematic
Marluce Rodrigues Godinho1, Fábio da Costa Carbogim1,2, Angélica da Conceição Oliveira Coelho1
1Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Objective:
The objective of this review is to evaluate the effect of prior aspiration vs no aspiration during intramuscular injection on the occurrence of adverse effects in adult patients.
Introduction:
Aspiration is a procedure conducted prior to the administration of intramuscular medications that aims to ensure that the needle tip is inserted in the proper place. Although aspiration is a common procedure, questions have been raised about adverse effects.
Inclusion Criteria:
This review will consider experimental and observational studies that include or evaluate the occurrence of any adverse effects following intramuscular injection, either with or without prior syringe aspiration, in adult patients. Adverse effects will include local pain, induration, puncture of blood vessels, decreased drug effect, hematoma, or abscess. The review will exclude studies on venipuncture, aspiration biopsies, or other invasive punctures of a diagnostic nature.
Methods:
This review will be conducted in accordance with the JBI methodology for systematic reviews of effectiveness. Databases to be searched will include PubMed, Embase, CINAHL, Scopus, LILACS, and Web of Science Core Collection, as well as sources of unpublished/gray literature, with no date or language limitations. Two independent reviewers will conduct study selection, critical appraisal, and data extraction. Studies will, where possible, be pooled in statistical meta-analysis. The grading of the certainty of evidence will be determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Registration Number:
PROSPERO CRD42021270432.
Related Concept Videos
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Parenteral Anesthetics: Overview
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Prevention of Further Absorption of Poison
Factors Affecting Drug Response: Overview

