Related Experiment Video
Updated: Jun 25, 2026
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
The Rodent Electronic Nicotine Delivery System: Apparatus for Voluntary Nose-Only E-Cigarette Aerosol Inhalation
Amy L Odum1, Mariah E Willis-Moore1, Kiernan T Callister1
1Utah State University.
Researchers developed a low-cost rodent model for electronic nicotine delivery systems (ENDS) to study vaping. This new system allows for effective nicotine aerosol self-administration in rats, aiding in the development of prevention strategies.
Area of Science:
- Neuroscience
- Pharmacology
- Public Health
Background:
- Electronic Nicotine Delivery Systems (ENDS) use, or vaping, is increasing, posing public health challenges.
- Preclinical models are crucial for understanding nicotine addiction and developing interventions.
- Existing models for nicotine self-administration have limitations.
Purpose of the Study:
- To develop a novel, low-cost, non-proprietary preclinical model for nicotine aerosol self-administration.
- To validate the functionality and effectiveness of the Rodent Electronic Nicotine Delivery System (RENDS).
Main Methods:
- Created the Rodent Electronic Nicotine Delivery System (RENDS), a nose-only aerosol delivery model.
- Measured fine particulate matter to confirm nicotine aerosol sequestration.
- Utilized operant chambers retrofitted with RENDS for self-administration studies.
Main Results:
- Rats robustly self-administered flavored nicotine aerosol via RENDS.
- High blood cotinine levels (nicotine metabolite) were observed in rats.
- Spontaneous somatic withdrawal symptoms were documented in rats exposed to nicotine aerosol.
Conclusions:
- The RENDS is a validated, functional, and cost-effective preclinical model for nicotine aerosol self-administration.
- This open-source model facilitates research into the effects of ENDS and nicotine addiction.
- RENDS can be implemented in existing operant chambers for under $325 per unit.
More Related Videos
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
08:39Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Related Concept Videos
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
01:29Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...