Related Experiment Video

Updated: Jun 3, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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UTX Coordinates TCF1 and STAT3 to Control Progenitor CD8+ T cell Fate in Autoimmune Diabetes

Ho-Chung Chen, Hsing Hui Wang, Lisa A Kohn

    Biorxiv : the Preprint Server for Biology
    |January 7, 2025
    PubMed
    Summary

    The epigenetic regulator UTX drives Type 1 Diabetes (T1D) by enabling progenitor CD8+ T cells to become harmful effectors. Inhibiting UTX protects mice from T1D, suggesting a new therapeutic target.

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