A biocompatible Ni(II) complex as an amyloid sensor for human PrP106-126 fibrillar aggregates
Rajat Saini1, Rahul Chauhan1, Sain Singh1
1Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India. kaushik.ghosh@cy.iitr.ac.in.
Abstract:
KRS-1, a biocompatible nickel(II) complex, is introduced as a potent fluorescent probe for PrP106-126 fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP106-126 aggregation. Fluorescence microscopy confirms its efficacy in identifying PrP106-126 fibrillar aggregates in HT-22 cells.


