JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Apparent diffusion coefficient and magnetic resonance imaging characteristics in predicting response to radiosurgery in patients with vestibular schwannomas

  • 0Division of Diagnostic Radiology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.
The Neuroradiology Journal +

|

January 7, 2025

|

January 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Predicting vestibular schwannoma (VS) treatment response is challenging. Pre-treatment normalized apparent diffusion coefficient (nADC) values in the solid tumor portion can help predict radiosurgery outcomes, aiding treatment planning.

Area Of Science

  • Neurosurgery
  • Radiology
  • Oncology

Background

  • Predicting treatment response in vestibular schwannomas (VSs) undergoing radiosurgery is complex.
  • Normalized apparent diffusion coefficient (nADC) and magnetic resonance (MR) imaging characteristics may offer predictive insights.

Purpose Of The Study

  • To evaluate pre-treatment nADC values and MR imaging features for predicting treatment outcomes in VS patients after radiosurgery.
  • To assess the utility of nADC in distinguishing between tumor control and progression.

Main Methods

  • Retrospective review of MR images from 44 VS patients treated with radiosurgery.
  • Analysis of pre-treatment nADC values (whole tumor and solid portion) and MRI characteristics.
  • Categorization into tumor control (n=28) and progression (n=16) groups with median follow-up of 29.5 months.

Main Results

  • Early post-treatment enlargement correlated with tumor progression (p = .024).
  • Mean pre-treatment nADC values for the solid tumor part were significantly higher in the tumor control group (1.32) versus the progression group (1.05) (p = .005).
  • An nADC cutoff of 1.18 demonstrated 76.2% sensitivity and 86.7% specificity for predicting treatment response.

Conclusions

  • Mean nADC values of the solid tumor portion are valuable predictors of radiosurgery response in VS patients.
  • Early post-treatment enlargement is a significant indicator of tumor progression.
  • Integrating nADC values into clinical practice can refine treatment strategies for VS.

Keywords: