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Elevated LINC00115 expression correlates with aggressive endometrial cancer phenotypes via JAK/STAT pathway
Zheqi Zhao1,2, Yangyang Liu3, Mengyao Wang3
1Department of Reproductive Medicine, The First Affiliated Hospital of Henan University of CM, No. 19, Renmin Road, Jinshui District, Zhengzhou City, Henan Province, China.
Human Molecular Genetics
|January 7, 2025
Summary
Long non-coding RNA LINC00115 promotes endometrial cancer (EC) progression by activating the JAK/STAT pathway. Targeting LINC00115 offers a new therapeutic strategy for EC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Endometrial cancer (EC) is a common gynecological malignancy.
- Long non-coding RNAs (lncRNAs) play crucial roles in cancer development.
- The specific role of LINC00115 in EC remains largely unexplored.
Purpose of the Study:
- To investigate the oncogenic function of LINC00115 in endometrial cancer.
- To elucidate the underlying molecular mechanism of LINC00115 in EC progression.
- To evaluate LINC00115 as a potential biomarker and therapeutic target for EC.
Main Methods:
- Analysis of LINC00115 expression in EC tissues and correlation with clinical parameters.
- In vitro functional assays (e.g., cell proliferation, invasion, migration) after LINC00115 knockdown or overexpression.
- In vivo tumor xenograft models to assess the effect of LINC00115 on tumor growth and metastasis.
- Investigation of the interaction between LINC00115, KHSRP, and the JAK/STAT pathway.
Main Results:
- LINC00115 is significantly upregulated in EC tissues and associated with advanced stage and lymph node metastasis.
- LINC00115 knockdown inhibits EC cell proliferation, invasion, and metastasis, while overexpression enhances these processes.
- LINC00115 directly interacts with KHSRP to activate the JAK/STAT signaling pathway.
- Overexpression of LINC00115 accelerates tumor growth and metastasis in vivo.
Conclusions:
- LINC00115 acts as an oncogenic lncRNA in endometrial cancer.
- LINC00115 promotes EC proliferation, invasion, and metastasis via the KHSRP-mediated JAK/STAT pathway.
- LINC00115 is a promising diagnostic biomarker and therapeutic target for endometrial cancer.
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