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Updated: Jun 3, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Technological advances in clinical individualized medication for cancer therapy: from genes to whole organism

Jiejing Kai1, Xueling Liu1, Meijia Wu1

  • 1Department of Clinical Pharmacy, Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Personalized Medicine
|January 7, 2025
PubMed

Insights

Leveraging technology for cancer treatment involves analyzing genomic and histological data. While personalized medicine advances, achieving precise tumor characteristic identification and drug response prediction remains a key goal for improved patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Technological advancements aim to precisely identify tumor characteristics and predict patient drug responses.
  • Genomic data, histological information, and drug metabolism studies are crucial for personalized medicine.

Purpose of the Study:

  • To summarize conventional and state-of-the-art technologies for individualized medication.
  • To explore therapy options for enhancing clinical outcomes in cancer patients.

Main Methods:

  • Utilizing diverse data sources: genomic, histological, functional drug profiling, and drug metabolism.
  • Employing techniques such as polymerase chain reaction, next-generation sequencing, and patient-derived models.
  • Incorporating therapeutic drug monitoring for treatment optimization.

Main Results:

  • Diverse detection technologies enable "individualized treatment" in clinical practice.
  • Current methods have advanced personalized medicine but have not yet reached the desired accuracy levels.
  • Ongoing research focuses on refining technologies for better prediction of drug efficacy.

Conclusions:

  • Accurate identification of tumor characteristics and drug response prediction are vital for effective cancer therapy.
  • Continued development and integration of advanced technologies are necessary to fully realize the potential of personalized medicine.
  • The exploration of novel therapeutic strategies aims to enhance clinical outcomes for cancer patients.
Keywords:
Personalized medicinegenetic detectionimmunohistochemistrypatient-derived organoidspatient-derived xenograftstherapeutic drug monitoring

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