The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient-Reported Outcomes in...

Area of Science:

• Oncology
• Radiology
• Body Composition Analysis

Background:

• Metastatic non-small-cell lung cancer (mNSCLC) presents complex challenges for treatment and survival.
• Patient-reported outcomes (PROs) are crucial for understanding the patient experience in mNSCLC.
• Body composition, often assessed via CT scans, may influence clinical outcomes in mNSCLC.

Purpose of the Study:

• To investigate the association between body composition parameters and overall survival in mNSCLC patients.
• To determine the relationship between body composition and the likelihood of receiving treatment for mNSCLC.
• To explore how body composition correlates with patient-reported outcomes (PROs) in mNSCLC.

Main Methods:

• Retrospective analysis of mNSCLC patients with available CT scans and PROs near diagnosis.
• Utilized Cox proportional hazard models for survival and logistic regression for treatment odds.
• Employed multiple linear regression to assess PROs and body composition, adjusting for clinical covariates.

Main Results:

• Greater skeletal muscle area linked to better physical function.
• Increased intermuscular adipose tissue associated with higher mortality risk and fatigue, and lower treatment odds.
• Larger subcutaneous and total adipose tissue areas correlated with improved survival and higher odds of receiving treatment.

Conclusions:

• Body composition at diagnosis is significantly associated with survival, treatment decisions, and PROs in mNSCLC.
• Routine CT scans and PROs can provide valuable data for optimizing treatment and supportive care in mNSCLC.
• Understanding body composition offers a novel approach to personalize mNSCLC management.