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Artificial Oxygen Carriers Save Lives in Expanded Access Use: Three Cases when Blood Was Not an Option
Zhen W Mei1, Jay S Raval2, Justin Arnall3
1Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
For sickle cell patients facing transfusion complications, hemoglobin-based oxygen carriers (HBOCs) offer a potential lifeline. Investigational HBOC-201 provided acute resuscitation, proving life-saving when conventional blood products were unavailable.
Area of Science:
- Hematology
- Transfusion Medicine
- Biomaterials
Background:
- Sickle cell disease patients frequently develop antibodies, complicating transfusions and leading to severe reactions like hyperhemolysis syndrome.
- Transfusion challenges in sickle cell patients necessitate alternative oxygen-carrying solutions when standard blood products are insufficient or unavailable.
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