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Updated: Jun 30, 2026

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Impaired spatial dynamic functional network connectivity and neurophysiological correlates in functional hemiparesis.

E Premi1, V Cantoni2, A Benussi3

  • 1Stroke Unit, ASST Spedali Civili, «Spedali Civili» Hospital, Brescia, Italy.

Neuroimage. Clinical
|January 7, 2025
PubMed
Summary

Patients with functional stroke mimics (FSM) exhibit altered brain network dynamics, specifically in the somatomotor network. These changes in dynamic functional connectivity correlate with GABAergic neurotransmission, suggesting potential therapeutic targets.

Keywords:
Dynamic functional network connectivityFunctional stroke mimicsIntracortical facilitation (ICF)Short interval intracortical inhibition (SICI)Spatial chronnectomeTranscranial magnetic stimulation (TMS)

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Area of Science:

  • Neuroscience
  • Functional Neuroimaging
  • Neurology

Background:

  • Functional hemiparesis, often mimicking stroke (functional stroke mimics, FSM), presents diagnostic challenges.
  • Understanding the underlying neural dynamics in FSM is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate spatial dynamic functional network connectivity (dFNC) in patients with FSM.
  • To assess alterations in brain states and their relationship with neurotransmission.

Main Methods:

  • Resting-state fMRI data were acquired from 15 FSM patients and 52 healthy controls (HC).
  • Spatial dFNC was evaluated across the somatomotor network (SMN), default mode network (DMN), and salience network (SN).
  • Transcranial magnetic stimulation was used to assess GABAergic and glutamatergic transmission.

Main Results:

  • FSM patients showed significantly reduced dwell time in a specific state of the SMN compared to HC.
  • FSM patients spent more time in specific states of the DMN and SN.
  • Impaired SMN dwell time correlated with increased GABAergic inhibition.

Conclusions:

  • FSM is associated with distinct alterations in dynamic functional brain network connectivity.
  • These dFNC changes are linked to GABAergic neurotransmission, indicating a potential neurochemical basis.
  • dFNC and GABAergic function represent promising targets for future therapeutic strategies in FSM.