Related Experiment Video
Updated: Jun 3, 2025
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
10.9K
UL24 herpesvirus determinants of pathogenesis: Roles in virus-host interactions
Angela Pearson1, Amel Bouhamar1
1Institut National de La Recherche Scientifique, Laval, Québec, Canada.
Virology
|January 7, 2025
Summary
Herpesvirus UL24 genes impact disease severity and are found across the Herpesviridae family. This review explores UL24
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- The UL24 gene family is conserved across the Orthoherpesviridae (Herpesviridae) family.
- UL24 proteins play roles in viral pathogenesis and host cell interactions.
Purpose of the Study:
- To review the impact of UL24 homologs on pathogenesis across various model systems.
- To elucidate the mechanistic roles of UL24 proteins in virus-host interactions.
- To discuss the potential of targeting UL24 for therapeutic development.
Main Methods:
- Review of existing literature on UL24 homologs.
- Analysis of studies utilizing different model systems to investigate pathogenesis.
- Examination of mechanistic studies on UL24 protein functions.
Main Results:
- UL24 homologs are critical determinants of herpesvirus pathogenesis.
- UL24 proteins exhibit diverse roles in modulating virus-host cell interactions.
- Evidence suggests UL24's involvement in viral replication and immune evasion.
Conclusions:
- UL24 proteins are key viral factors influencing disease outcomes.
- Understanding UL24 mechanisms can reveal novel therapeutic targets.
- Targeting UL24 offers a promising strategy for antiviral therapies against herpesviruses.
Related Concept Videos
02:33Retroviruses
12.2K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.2K
01:10Retrovirus Life Cycles
45.6K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.6K
01:29Immune Response Against Viral Pathogens
742
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
742
01:51Mechanisms of Retrovirus-induced Cancers
5.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.0K
00:56Viral Structure
61.7K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
61.7K